What Should You Know About Using Isotretinoin?

Isotretinoin 20mg, commonly known by brand names like Accutane, Claravis, and Roaccutane, is a powerful medication primarily used to treat severe acne that hasn’t responded to other treatments. While it's widely regarded as one of the most effective acne therapies, isotretinoin also comes with a range of important precautions, potential side effects, and strict guidelines for safe use.

Whether you're considering isotretinoin or have just started a course, this article will walk you through everything you need to know, including how it works, what to expect, safety tips, and more.

What Is Isotretinoin?

Isotretinoin from dosepharmacy is an oral retinoid, derived from vitamin A, that dramatically reduces sebum (oil) production, inflammation, and bacterial growth in the skin. It also helps prevent clogging of pores, which is central to the development of acne.

Unlike topical treatments, isotretinoin treats acne at its root cause, making it effective even for nodulocystic or scarring acne.

Who Should Use Isotretinoin?

Isotretinoin is typically prescribed for:

Severe nodular or cystic acne

Acne resistant to antibiotics or topical therapies

Acne that causes physical or emotional scarring

Chronic acne that flares frequently

It is not usually the first treatment option and is reserved for individuals who haven't responded to conventional treatments like topical retinoids, benzoyl peroxide, or oral antibiotics.

How Is Isotretinoin Taken?

Isotretinoin is taken orally in capsule form, usually once or twice a day, depending on your doctor’s recommendation. It’s best absorbed with a high-fat meal to enhance absorption.

The treatment typically lasts for 4 to 6 months, but may vary depending on:

The severity of your acne

Your body weight

Your individual response to the medication

A second course may be prescribed if acne recurs after the first cycle.

Key Things You Should Know Before Starting

1. Birth Control Is Mandatory for Women

Isotretinoin can cause severe birth defects if taken during pregnancy. For this reason, women of childbearing age must:

Use two forms of birth control one month before, during, and one month after treatment.

Take regular pregnancy tests (usually monthly).

Enroll in a monitoring program like iPLEDGE in the U.S.

Pregnancy while on isotretinoin is considered a medical emergency.

2. Regular Blood Tests Are Required

Your doctor may order monthly blood tests to monitor for:

Liver function

Cholesterol and lipid levels

Kidney function

White blood cell count

These tests help detect any internal issues early, since isotretinoin can impact organ function in rare cases.

3. Dryness Is the Most Common Side Effect

The most commonly reported side effect is dryness, particularly of the:

Lips (cracked, peeling)

Nose (may cause nosebleeds)

Skin (dry, peeling, or sensitive)

Eyes (dry or irritated)

Be sure to use a good lip balm, moisturizer, and eye drops daily.

4. Mental Health Monitoring

There have been reports of mood changes, depression, and anxiety in some people taking isotretinoin. While not common, it's important to:

Monitor your mental health

Communicate with your doctor if you feel unusually sad, anxious, or have thoughts of self-harm

Have support from friends and family during treatment

5. Sun Sensitivity Increases

Isotretinoin makes your skin much more sensitive to UV rays. To avoid sunburn:

Use broad-spectrum sunscreen daily

Wear hats and protective clothing

Avoid tanning beds and prolonged sun exposure

6. Avoid Certain Medications and Procedures

While on isotretinoin, you should avoid:

Vitamin A supplements (can increase toxicity)

Tetracycline antibiotics (can raise risk of intracranial pressure)

Laser treatments, waxing, or dermabrasion (skin is too sensitive and may scar)

Always tell your doctor about all other medications and supplements you’re taking.

Potential Side Effects

While many people tolerate isotretinoin well, side effects can vary in severity.

Common Side Effects:

Dry skin and lips

Peeling fingertips or soles

Nosebleeds

Joint or muscle pain

Increased skin sensitivity

Less Common But Serious:

Mood changes

Vision or hearing changes

Severe stomach pain

Blood in stool

Liver enzyme elevation

If you experience serious symptoms, stop the medication and consult your doctor immediately.

Does Isotretinoin Cure Acne?

In many cases, yes—isotretinoin can provide a long-term or permanent solution to acne. Studies show that:

Up to 85% of patients experience complete or near-complete clearance

Many do not need further acne treatment after finishing a course

Some may require a second course or occasional topical treatments

However, results vary, and not everyone responds the same way.

Tips for a Safe and Comfortable Treatment

Hydration is key: Drink plenty of water and use gentle moisturizers.

Stick to a gentle skincare routine: Avoid harsh cleansers and exfoliants.

Plan your treatment wisely: Avoid starting during stressful times or before major life events due to potential mood changes and visible skin dryness.

Communicate openly with your dermatologist: Don’t hesitate to report side effects or concerns.

Don’t share your medication: Isotretinoin is prescribed based on individual medical needs and should never be used by someone else.

After Treatment: What to Expect

Once you complete your isotretinoin course:

Your skin may continue improving for several months.

Some dryness may linger but typically resolves.

Scars from previous acne may fade over time.

You may need maintenance treatments or topical products for occasional breakouts.

Most importantly, continue good skincare habits and follow up with your dermatologist as needed.

Final Thoughts

Isotretinoin is a life-changing medication for many people struggling with severe or persistent acne. Its ability to deliver long-term results is unmatched, but it requires careful use, monitoring, and awareness of its side effects and responsibilities.

If you're considering isotretinoin, talk to a dermatologist about whether it's the right treatment for you. With proper guidance and care, it can lead to clear skin, improved confidence, and relief from years of frustrating breakouts.